Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing. (Nature Cell Biology)
Depletion of Per2 leads to a stabilization of the number of immune cells in the blood of aged mice and prolongs their lifespan.
Long non-coding RNA Lnc34a is enriched in colon cancer stem cells and initiates asymmetric division by targeting the microRNA miR-34a to cause its spatial imbalance.
Depletion of Smad4 and PTEN in Lgr5+ cells leads to a rapid onset and progression from microadenoma and macroscopic adenoma to invasive intestinal-type gastric cancer.
Overexpression of Twist increased expression of PAR1 (an upstream regulator of the Hippo pathway), promoting invasion, migration, and cancer stem cell-like properties in breast cancer by activating the transcriptional co-activator TAZ.