May 2016

SUNRISE members Publications

Autocrine secretion of progastrin promotes the survival and self-renewal of colon cancer stem-like cells. (Cancer Res.)

A Positive Feed-forward Loop Associating EGR1 and PDGFA Promotes Proliferation and Self-renewal in Glioblastoma Stem Cells. (J Biol Chem)

 

PUBLICATIONS

Cancer Stem-Like Properties in Colorectal Cancer Cells with Low Proteasome Activity. (Clin Canser Res)

Cells with  low proteasome activity (according to the expression of a green fluorescent molecule fused to the degron of ornithine decarboxylase ) have characteristic treatment resistance and act as CSCs in CRC.

 The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing (Cell Rep)

The insulin-like growth factor 2 mRNA-binding protein 2 (IMP2) binds to let-7 miRNA recognition elements (MREs) and prevents let-7 target gene silencing leading to GBM stem cells differentiation.

 The Marrow Niche Controls the Cancer Stem Cell Phenotype of Disseminated Prostate Cancer (Oncotarget)

The hematopoietic stem cells niche plays a significant role in maintaining tumor-initiating prostate cancer in marrow and suggests a functional relationship between CSCs and dormancy.

 Hepatocellular Carcinoma: Thyroid Hormone Promotes Tumorigenicity through Inducing Cancer Stem-Like Cell Self-Renewal (Sci Rep)

Thyroid hormone (TH) and Thyroid Receptor alpha (TRa) promotes cell self-renewal and chemoresistance in HCC cells.