Zena Werb (UCSF) passed away this last June 17th. She was a great cell biologist that made major breakthrough in mammary stem cell biology. She produced seminal works describing the mechanics of mammary gland morphogenesis. Using elegant models Zena revealed the complex interplay between the breast cancer stem cells and its niche.
A great way to pay tribute to this amazing scientist is to read or revisit some of her last publications:
- Plaks V, et al. The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells? Cell Stem Cell. 2015
- Lawson DA, et al. Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature. 2015.
- Plaks V, et al. Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Rep. 2013
- Kessenbrock K, et al. A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell Stem Cell. 2013
- Welm BE, et al. Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer. Cell Stem Cell. 2008