Cancer Epigenetics: Concepts, Challenges and Therapeutic Opportunities
13th of September, 2021- 12am (Time zone: Europe, Paris)
LINK to the webinar: HERE
Biography: Mark Dawson is a clinician-scientist at the Peter MacCallum Cancer Centre and Centre for Cancer Research University of Melbourne (Australia). His work focuses on understanding the role that epigenetic regulators play in the initiation and maintenance of cancer. Moreover, he uncovers several epigenetic mechanisms by which malignancies evade therapeutic pressure. He pioneered the development of BET inhibitor and the use of click chemistry in vivo.
Key publications
O. Gilan, I. Rioja, K. Knezevic, M.J. Bell, M.M. Yeung, N.R. Harker, E.Y.N. Lam, C.W. Chung, P. Bamborough, M. Petretich, M. Urh, S.J. Atkinson, A.K. Bassil, E.J. Roberts, D. Vassiliadis, M.L. Burr, A.G.S. Preston, C. Wellaway, T. Werner, J.R. Gray, A.M. Michon, T. Gobbetti, V. Kumar, P.E Soden, A. Haynes, J. Vappiani, D.F. Tough, S. Taylor, S.J. Dawson, M. Bantscheff, M. Lindon, G. Drewes, E.H. Demont, D.L. Daniels, P. Grandi, R.K. Prinjha & M.A. Dawson – “Selective targeting of BD1 and BD2 of the BET proteins in cancer and immune-inflammation”. Science; 2020 Apr 24; 368(6489):387-394.
L. MacPherson, J. Anokye, M.M. Yeung, E.Y.N. Lam, Y-C. Chan, C-F. Weng, P. Yeh, K. Knezevic, M.S. Butler, A. Hoegl, K-L. Chan, M.L. Burr, L.J. Gearing, T. Willson, J. Liu, J. Choi, Y. Yang, R.A. Bilardi, H. Falk, N. Nguyen, P. Stupple, T.S. Peat, M. Zhang, M. de Silva, C. Carrasco-Pozo, V.M. Avery, P.S. Khoo, O. Dolezal, M.L. Dennis, S. Nuttall, R. Surjadi, J. Newman, B. Ren, D.J. Leaver, Y. Sun, J.B. Baell, O. Dovey, G.S. Vassiliou, F. Grebien, S.J. Dawson, I.P. Street, B.J. Monahan, C.J. Burns, C. Choudhary, M.E. Blewitt, A.K. Voss, T.Thomas & M.A. Dawson – “HBO1 is required for the maintenance of leukaemia stem cells”. Nature; 2020 Jan; 577(7789):266-270.
M.L. Burr, C. E. Sparbier, K. L. Chan, Y.C. Chan, A. Kersbergen, E.Y.N. Lam, E. Azidis-Yates, D. Vassiliadis, C.C. Bell, O. Gilan, S. Jackson, L. Tan, S.Q. Wong, S. Hollizeck, E.M. Michalak, H.V. Siddle, M.T. McCabe, R.K. Prinjha, G.R. Guerra, B.J. Solomon, S. Sandhu, S.J. Dawson, P.A. Beavis, R.W. Tothill, C. Cullinane, T.J. Lehner, K.D. Sutherland & M.A. Dawson – “An evolutionary conserved function of polycomb silences the MHC Class I antigen presentation pathway and enables immune evasion in cancer”. Cancer Cell. 2019 Oct 14;36(4):385-401.
C.C. Bell, K.A. Fennell, Y.C. Chan, F. Rambow, M.M. Yeung, D. Vassiliadis, L. Lara, P. Yeh, L.G. Martelotto, A. Rogiers, B.E. Kremer, O. Barbash, H.P. Mohammad, T.M. Johanson, M.L. Burr, A. Dhar, N. Karpinich, L. Tian, D.S. Tyler, L. MacPherson, J. Shi, N. Pinnawala, C.Y. Fong, A.T. Papenfuss, S.M. Grimmond, S.J. Dawson, R.S. Allan, R.G. Kruger, C.R. Vakoc, D.L. Goode, S.H. Naik, O. Gilan, E.Y.N. Lam, J.C. Marine, R.K. Prinjha & M.A. Dawson – “Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia”. Nature Communications. 2019 Jun 20;10(1):2723.
M. Burr, CE. Sparbier, YC. Chan, JC. Williamson, K. Woods, PA. Beavis, EYN. Lam, MA. Henderson, CC. Bell, S. Stolzenburg, O. Gilan, S. Bloor, T. Noori, D. Morgens, MC. Bassik, PJ. Neeson, A. Behren, PK. Darcy, SJ. Dawson, I. Voskoboinik, J. Trapani, J. Cebon, PJ. Lehner & M.A. Dawson – “CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity”. Nature, 2017 Sep 7; 549(7670): 101-105.
