Cancer Epigenetics: Concepts, Challenges and Therapeutic Opportunities
13th of September, 2021- 12am (Time zone: Europe, Paris)
LINK to the webinar: HERE
Professor Dawson is a clinician-scientist at the Peter MacCallum Cancer Centre and Centre for Cancer Research University of Melbourne (Australia)
In Mark Dawson’s laboratory, researchers aim to develop a molecular understanding of the role that epigenetic regulators play in the initiation and maintenance of cancer and uncover the epigenetic mechanisms by which malignancies evade therapeutic pressure.
Publications récentes:
O. Gilan, I. Rioja, K. Knezevic, M.J. Bell, M.M. Yeung, N.R. Harker, E.Y.N. Lam, C.W. Chung, P. Bamborough, M. Petretich, M. Urh, S.J. Atkinson, A.K. Bassil, E.J. Roberts, D. Vassiliadis, M.L. Burr, A.G.S. Preston, C. Wellaway, T. Werner, J.R. Gray, A.M. Michon, T. Gobbetti, V. Kumar, P.E Soden, A. Haynes, J. Vappiani, D.F. Tough, S. Taylor, S.J. Dawson, M. Bantscheff, M. Lindon, G. Drewes, E.H. Demont, D.L. Daniels, P. Grandi, R.K. Prinjha & M.A. Dawson – “Selective targeting of BD1 and BD2 of the BET proteins in cancer and immune-inflammation”. Science; 2020 Apr 24; 368(6489):387-394.
L. MacPherson, J. Anokye, M.M. Yeung, E.Y.N. Lam, Y-C. Chan, C-F. Weng, P. Yeh, K. Knezevic, M.S. Butler, A. Hoegl, K-L. Chan, M.L. Burr, L.J. Gearing, T. Willson, J. Liu, J. Choi, Y. Yang, R.A. Bilardi, H. Falk, N. Nguyen, P. Stupple, T.S. Peat, M. Zhang, M. de Silva, C. Carrasco-Pozo, V.M. Avery, P.S. Khoo, O. Dolezal, M.L. Dennis, S. Nuttall, R. Surjadi, J. Newman, B. Ren, D.J. Leaver, Y. Sun, J.B. Baell, O. Dovey, G.S. Vassiliou, F. Grebien, S.J. Dawson, I.P. Street, B.J. Monahan, C.J. Burns, C. Choudhary, M.E. Blewitt, A.K. Voss, T.Thomas & M.A. Dawson – “HBO1 is required for the maintenance of leukaemia stem cells”. Nature; 2020 Jan; 577(7789):266-270.
M.L. Burr, C. E. Sparbier, K. L. Chan, Y.C. Chan, A. Kersbergen, E.Y.N. Lam, E. Azidis-Yates, D. Vassiliadis, C.C. Bell, O. Gilan, S. Jackson, L. Tan, S.Q. Wong, S. Hollizeck, E.M. Michalak, H.V. Siddle, M.T. McCabe, R.K. Prinjha, G.R. Guerra, B.J. Solomon, S. Sandhu, S.J. Dawson, P.A. Beavis, R.W. Tothill, C. Cullinane, T.J. Lehner, K.D. Sutherland & M.A. Dawson – “An evolutionary conserved function of polycomb silences the MHC Class I antigen presentation pathway and enables immune evasion in cancer”. Cancer Cell. 2019 Oct 14;36(4):385-401.
C.C. Bell, K.A. Fennell, Y.C. Chan, F. Rambow, M.M. Yeung, D. Vassiliadis, L. Lara, P. Yeh, L.G. Martelotto, A. Rogiers, B.E. Kremer, O. Barbash, H.P. Mohammad, T.M. Johanson, M.L. Burr, A. Dhar, N. Karpinich, L. Tian, D.S. Tyler, L. MacPherson, J. Shi, N. Pinnawala, C.Y. Fong, A.T. Papenfuss, S.M. Grimmond, S.J. Dawson, R.S. Allan, R.G. Kruger, C.R. Vakoc, D.L. Goode, S.H. Naik, O. Gilan, E.Y.N. Lam, J.C. Marine, R.K. Prinjha & M.A. Dawson – “Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia”. Nature Communications. 2019 Jun 20;10(1):2723.
M. Burr, CE. Sparbier, YC. Chan, JC. Williamson, K. Woods, PA. Beavis, EYN. Lam, MA. Henderson, CC. Bell, S. Stolzenburg, O. Gilan, S. Bloor, T. Noori, D. Morgens, MC. Bassik, PJ. Neeson, A. Behren, PK. Darcy, SJ. Dawson, I. Voskoboinik, J. Trapani, J. Cebon, PJ. Lehner & M.A. Dawson – “CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity”. Nature, 2017 Sep 7; 549(7670): 101-105.
